The Interference of Monoclonal Anti-Cluster of Differentiation 47 on Transfusion Compatibility Testing

Hu5F9-G4 and AK117, novel cluster of differentiation 47 blockers, are used to treat solid tumors hematoma. Because is expressed on erythrocytes, treatment with monoclonal anti-cluster may interfere the results transfusion compatibility testing. This study analyzed interference AK117 Saline microcolumn gel methods were identify blood types patients. To screen irregular antibodies, salt water, indirect antiglobulin test polyamine used. Various including saline, test, acid diffusion. paper explores current for removing caused by 47. interferes reverse typing ABO groups, resulting in agglutination all reagents antibody screening identification. Patients’ erythrocyte dispersive fluid reacted positively spectrum cells erythrocytes treated papain serum. In saline coagulant amine media, did not agglutinate cells, but it antihuman globulin media. Pre-transfusion testing can be interfered antibodies. ensure safe transfusions, patients should have their type tested antibodies screened before treatment.